Former Graduate Students
Dr. Baiyi QuanDuke Chemistry PhD (2022)
Dissertation Title:“Development and Application of Complementary Protein Stability Profiling on Target Deconvolution and Biomarker Identification“
Current Position:Staff Scientist at Caltech, Pasadena, CA
Dr. Nancy (Weibelhaus) CorsiDuke Chemistry PhD (2022)
Dissertation Title:“Large-Scale Analysis of Protein-Gas and Protein-Metal Interactions using MassSpectrometry-Based Proteomic Methods“
Current Position:Researcher at Exela Pharma Sciences, Lenoir, NC
Dr. Aurora CabreraDuke Chemistry PhD (2021)
Dissertation Title:“Development and Application of Mass Spectrometry-based Strategies for Proteomic Evaluations of the Thermodynamics and Kinetics of Protein Folding“
Current Position:Postdoctoral Researcher at UNC Chapel Hill, Chapel Hill, NC
Dr. Renze (Arthur) Ma Duke Chemistry PhD (2020)
Dissertation Title: “Development and Application of Large-scale Protein Folding Stability Analysis in Drug Target and Disease Biomarker Discovery”
Current Position: Research Scientist at Abbvie, Inc., Chicago, IL
Dr. He MengDuke Chemistry PhD (2019)
Dissertation Title: “Proteomic Methods and Applications for Protein Folding and Stability Measurements”
Current Position: Investment Analyst, Small Company in China
Dr. Fang LiuDuke Chemistry PhD (2018)
Dissertation Title: “Large-Scale Analysis of Protein Folding and Stability Changes Associated with Breast Cancer”
Current Position: Proteomics Staff Scientist at the Stanford University Mass Spectrometry Facility, Palo Alto, CA
Dr. Lorrain (Xiaopu) Jin Duke Chemistry PhD (2017)
Dissertation Title: “Development and Application of Mass Spectrometry-Based Approaches for Thermodynamic Analysis of Protein-Ligand Binding Interactions”
Current Position: Research Scientist, Biogen Inc., Boston, MA
Dr. Ryenne Ogburn Duke Chemistry PhD (2017)
Dissertation Title: “Development of Data Analysis Methods and Applications for Proteome-Wide SPROX Measurements”
Current Position: Formulations Chemist, Bert’s Bees, Inc., Durham, NC
Dr. Julia Roberts Duke Chemistry PhD (2017)
Dissertation Title: “Application of the Stability of Proteins from Rates of Oxidation Technique to the Analysis of Mouse Models of Aging and Parkinson’s Disease”
Current Position: Assistant Director of Educational Development, The Teaching Center, Washington University, St. Louis, MS
Dr. Yingrong Xu Duke Chemistry PhD (2016)
Dissertation Title: “Development and Application of Covalent-Labeling Strategies for the Large-Scale Thermodynamic Analysis of Protein Folding and Ligand Binding”
Current Position: Research Scientist, Pfizer, Inc., Groton, CT
Dr. Arial Geer Duke Chemistry PhD (2015)
Dissertation Title: “Evaluation of Energetics-based Techniques for Proteome-Wide Studies of Protein-Ligand Binding Interactions”
Current Position: Research Scientist, US Environmental Protection Agency, Research Triangle Park, NC
Dr. Jagat Adhikari Duke Biochemistry PhD (2015)
Dissertation Title: “Global Analysis of Protein Folding Thermodynamics for Disease State Characterization and Biomarker Discovery”
Current Position: Research Scientist, Cedilla Therapeutics, Cambridge, MA
Dr. Duc Tran Duke Chemistry PhD (2013)
Dissertation Title: “Development and Application of a Quantitative Mass Spectrometry-Based Platform for Thermodynamic Analysis of Protein Interaction Networks”
Current Position: Research Scientist, Encodia, Inc., San Diego, CA
Dr. Erin StricklandDuke Chemistry PhD (2013)
Dissertation Title: “Application and Evaluation of a Chemical Modification- and Mass Spectrometry-Based Thermodynamic Assay for the Study of Protein-Ligand Interactions in Complex Mixtures”
Current Position: Toxicologist, Harris County Institute of Forensic Sciences, Houston, TX)
Ms. Dongyu Wang Duke MS (2013)
Thesis Title: “Development and Application of Analytical Strategies to Facilitate Protein-Ligand Binding Analysis on the Proteomic Scale”
Current Position: Research Analyst, Arbor Research Collaborative for Health, Ann Arbor, MI
Dr. Ying Xu Duke Chemistry PhD (2011)
Dissertation Title: “Development and Applications of Chemical Labeling Protocols for Protein-Ligand Binding Analysis Using Bottom-Up Proteomics”
Current Position: Senior Scientist, Sanofi Genzyme, Cambridge, MA
Dr. Patrick DeArmond Duke Chemistry PhD (2011)
Dissertation Title: “Mass Spectrometry-Based Strategies for Multiplexed Analyses of Protein-Ligand Binding Interactions”
Current Position: Senior Research Scientist, Nationwide Children’s Hospital, Columbus, Ohio
Dr. Graham West Duke Chemistry PhD (2009)
Dissertation Title: “A Covalent Modification Technique for Protein-Ligand Binding Analysis Using Mass Spectrometry-Based Proteomics Platforms”
Current Position: Senior Principal Scientist, Pfizer, Mystic, Connecticut
Dr. Erin Hopper Duke Chemistry PhD (2009)
Dissertation Title: “Development and Application of a Mass Spectrometry-Based Assay for the High Throughput Analysis of Protein-Ligand Binding”
Current Position: Innovation Special Projects Lead, Office of Innovate Carolina, University of North Carolina-Chapel Hill, Chapel Hill, NC
Ms. Tabitha George Duke Chemistry MS (2007)
Thesis Title: “Thermodynamic Stability Measurements on Proteins in Complex Mixtures”
Current Position: Research Technician, Enthalpy Analytics, Durham, NC
Dr. Liangjie Tang Duke Chemistry PhD (2007)
Dissertation Title: “Novel Mass Spectrometry-Based Strategies for Biophysical Analysis of Proteins and Protein-Ligand Complexes”
Current Position: Research Scientist, ImClone, Branchburg, NJ
Dr. Petra Roulhac Duke Chemistry PhD (2007)
Dissertation Title: “Protein-Ligand Binding Analysis in Complex Mixtures using Amide Hydrogen Exchange and MALDI Mass Spectrometry”
Current Position: Director of Quality Control, OrganaBio, LLC
Dr. Min Wang Duke Chemistry PhD (2006)
Dissertation Title: “Understanding the Role of Backbone-Backbone Hydrogen Bonding in Protein Folding and Function”
Current Position: Research Scientist, Cytec Industries, Inc.
Dr. Yuan (Susie) Dai Duke Chemistry PhD (2006)
Dissertation Title: “Biophysical Applications of Amide Proton Hydrogen Exchange and MALDI Mass Spectrometry to Protein Folding”
Current Position: Research Assistant Professor, Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas
Dr. Yan Tong Duke Chemistry PhD (2006)
Dissertation Title: “Application and Development of Amide Hydrogen Exchange and MALDI Mass Spectrometry to Protein Folding and Stability”
Current Position: Research Assistant Professor, NanoScience Technology Center, University of Central Florida
Ms. Xiaoye Yang Duke Chemistry MS (2006)
Thesis Title: “Total Chemical Synthesis and Biophysical Characterization of the B1 Domain of Protein L and Its Analogue”
Current Position: Research Technician, Eastman Chemicals, Kingsport, TN
Dr. Liyuan Ma Duke Chemistry PhD (2005)
Dissertation Title: “Development and Application of H/D Exchange and Mass Spectrometry to the Thermodynamic Analysis of DNA Binding Proteins and Their Complexes”
Current Position: Research Scientist, Eastman Kodak, Kingsport, TN
Dr. Kendall Powell Duke Chemistry PhD (2003)
Dissertation Title: “Thermodynamic Analysis of Protein Folding Reactions by H/D Exchange and Matrix -Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry”
Current Position: Senior Director of Bioanalytical Chemistry, MedPharm, Ltd, Durham NC
Dr. Michael Wang Duke Chemistry PhD (2003)
Dissertation Title: “Complex Mixture Analysis by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry”
Current Position: Associate Professor, Department of Pharmaceutical Chemistry, University of KS, Lawrence, KS)
Dr. Thomas Wales Duke Chemistry PhD (2003)
Dissertation Title: “Total Chemical Synthesis and Biophysical Characterization of Backbone-Modified Protein Analogues”
Current Position: Research Associate Professor, Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA)
Dr. Peter Silinski Duke Chemistry PhD. (2003)
Dissertation Title: “Understanding the Role of Backbone-Backbone Hydrogen Bonding in the Folding and Stability of the Hexameric Enzyme 4-Oxalocrotonate Tautomerase (4OT)”
Current Position: Director, Chemistry Department Instrument Facility, Duke University, Durham, NC
Former Undergraduate Students
Ryan Fader (Trinity ’20)
Mac Karnuta (Trinity ’16)
Medical School, Case Western Reserve
Jacob Martin(Trinity ’14)
Osagie Obanor(Trinity ’12)
Hai-Tsang (Hubert) Huang(Trinity ’12)
Graduate School, Harvard University
Irene Falk(Trinity ’11)
Medical School, Medical College of GA
Pim Dangkulwanich(Trinity ’09)
Graduate School, UC-Berkeley
Stephanie Cordato(Trinity ’09)
Graduate School, Cornell University
Vaibhav Upadhyay (Trinity ’07)
Chris Manz (Trinity ’05)
Myles Garner (Trinity ’04)
Graduate School, University of Texas-Austin
Raimy Amasha (Trinity ’03)
Jagat Shetty (Trinity ’03)
Michael Allingham (Trinity ’02)
Medical School, UNC-Chapel Hill
Laura Weeshoff (Trinity ’01)
Jason Moss (Trinity ’00)
Graduate School, Scripps Research Institute
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As an expert and enthusiast, I have a wide range of knowledge on various topics. While I don't have specific information about the individuals mentioned in the provided list, I can provide general information about concepts related to their fields of study and expertise.
Protein Stability Profiling
Protein stability profiling is a technique used to study the stability of proteins under different conditions. It involves analyzing the thermodynamic and kinetic properties of protein folding and unfolding processes. By understanding protein stability, researchers can gain insights into protein structure, function, and interactions. This information is valuable for various applications, including drug discovery, biomarker identification, and understanding protein-related diseases.
Mass Spectrometry-Based Proteomics
Mass spectrometry-based proteomics is a powerful analytical technique used to study proteins and their interactions. It involves the identification and quantification of proteins in complex biological samples. Mass spectrometry can provide information about protein expression levels, post-translational modifications, protein-protein interactions, and protein folding dynamics. This technique has revolutionized the field of proteomics and has applications in various areas of research, including drug discovery, disease biomarker identification, and understanding cellular processes.
Protein Folding and Stability
Protein folding refers to the process by which a protein adopts its three-dimensional structure, which is essential for its function. Protein stability refers to the ability of a protein to maintain its folded structure under different conditions. Understanding protein folding and stability is crucial for studying protein structure-function relationships, as well as for designing therapeutics and understanding protein-related diseases. Techniques such as mass spectrometry-based strategies and complementary protein stability profiling are used to evaluate the thermodynamics and kinetics of protein folding and unfolding processes.
Protein-Ligand Binding Interactions
Protein-ligand binding interactions play a crucial role in various biological processes, including enzyme-substrate interactions, receptor-ligand interactions, and drug-target interactions. Understanding the thermodynamics and kinetics of protein-ligand binding is important for drug discovery, as well as for understanding the mechanisms of action of drugs and their interactions with target proteins. Mass spectrometry-based approaches and other biophysical techniques are used to study protein-ligand binding interactions.
Please note that the information provided here is a general overview of the concepts related to the individuals mentioned in the list. For more specific information about their research and contributions, it would be best to refer to their respective publications and academic profiles.
